PUFA are remarkably estrogenic, toxic to the ovaries

One of the few studies that looks into the issue of whether the xenoestrogenic burden we are exposed to 24×7 in Western countries is due entirely to synthetic, industrial chemicals or if there is more to the story. Well, there is definitely more to the story, and the additional evidence we have from the study … Read more

PUFA required for periodontal disease, aspirin may help

It is common knowledge even among mainstream dentists that periodontal disease is caused by bacteria accumulating under the gums, which over time leads to chronic inflammation and thus destruction of both gum tissue and the alveolar/jaw bone underneath the gums. Another “new” discover is that microbiome overgrowth (and thus endotoxin/LPS production) is also involved and … Read more

Protein and saturated fats beneficial, PUFA detrimental for thyroid

A good new study, which again confirms that saturated fat is anything but detrimental to our health. Most of the studies until now demonstrating improved thyroid function from saturated fat used coconut oil, and that has led to attacks from mainstream medicine that this pro-thyroid and healthy effect is unique to the coconut oil due … Read more

Maternal high-PUFA diet causes alcoholism, aggressiveness, early puberty, and hyper-estrogenism in offspring

Finally, an intervention study that should help convince some of the die-hard PUFA fans that these fatty acids are far from benign/beneficial, but in fact can cause a variety of chronic diseases. A very important finding of the study, that distinguishes it from other PUFA studies, is that it demonstrates without a doubt the estrogenicity … Read more

Inflammation (from PUFA), not telomeres, determines lifespan / healthspan

The idea of lifespan being entirely determined by limits on cellular division has ruled biology for more than a century and is perhaps best exemplified by the (in)famous (and false) Hayflick limit. Reaching the said limit is postulated to be controlled by telomere length, and as such the simplistic hypothesis materialized that could extend/control lifespan … Read more

PUFA metabolites may drive bacterial infections and their resistance to antibiotics

The study below demonstrates yet again that there is hardly an aspect of human health that PUFA does not influence in a detrimental manner, even seemingly non-metabolic aspects such as bacterial infections. As it turns out, most bacteria express the enzyme family known as lipoxygenases (LOX) and uses those enzymes to evade the endogenous immune … Read more

DHT / Progesterone / aspirin treat, cortisol ineffective, PUFA promotes prostate cancer

A great study, albeit in-vitro, that once again throws into doubt the entire hypothesis behind prostate cancer. First, it proves the key role of PUFA in the genesis and progression of prostate cancer by demonstrating that inhibitors of the COX enzyme (responsible for synthesizing prostaglandins from PUFA) are therapeutic even when used as a monotherapy. … Read more

PUFA promote torpor / hibernation, decrease lifespan

Not many studies on this topic, but here is one that will hopefully satisfy my critics who keep complaining that there is no evidence for the anti-metabolic, pro-hibernation effects of PUFA. Apparently, PUFA is sought after by hibernating animals (but even they consume it within very tightly controlled amounts/seasons) and universally avoided by non-hibernating ones … Read more

PUFA are potent immunosuppresive agents

Just a quick post for all those PUFA/fish-oil lovers who keep sending me hate-mail about the “incredibly beneficial” omega-3, and even omega-6 (e.g. some athletes/bodybuilders tout arachidonic acid as a natural “anabolic agent”). As the study below discusses, all PUFA, but especially omega-3, are about as potent as glucocorticoids in inducing T-cell death. Modern medicine … Read more

Blocking PUFA/prostaglandins restores metabolism and reverses brain aging

The bad news for PUFA has been accumulating for decades, yet public health authorities continue to claim that type of fat is “essential”. Whatever indirect admissions of the pathological role of PUFA in both chronic and acute/infectious diseases is given to the public, is usually confined to the well-known PUFA metabolites known as prostaglandins. However, … Read more